Acute toxicity
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Oral toxicity:
Irritating (forecast) (LD50: >2000 mg/kg). Based on testing of similar products and/or components.
Dermal toxicity:
Practically non-toxic (LD50: greater than 2000 mg/kg). Based on testing of similar products and/or components.
Inhalation toxicity:
Irritating (LD50: >5 mg/l). Based on testing of similar products and/or components.
Eye irritation:
May cause mild irritation. Based on testing of similar products and/or components.
Skin irritation:
May cause mild irritation in case of prolonged or repeated contact. Based on testing of similar products and/or components.
Other acute toxicity data:
Although an acute inhalation study was not performed with this product, a variety of mineral and synthetic oils, such as those in this product, have been tested. These samples had virtually no effect other than a non-specific inflammatory response in the lung to the aerosolized mineral oil. The presence of additives in other tested formulations (in approximately the same amounts as in the present formulation) did not alter the observed effects.
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Subchronic toxicology (summary)
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No significant adverse effects were found in studies using repeated dermal applications of similar formulations to the skin of laboratory animals for 13 weeks at doses significantly higher than those expected during normal industrial exposure. The animals were evaluated extensively for effects of exposure (hematology, serum chemistry, urinalysis, organ weights, microscopic examination of tissues etc.).
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Reproduction toxicology (summary)
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No teratogenic effects would be expected from dermal exposure, based on laboratory developmental toxicity studies of major components in this formulation and/or materials of similar composition.
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Chronic toxicology (summary)
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Repeated and/or prolonged exposure may cause irritation to the skin, eyes or respiratory tract. Overexposure to oil mist may result in oil droplet deposition and/or granuloma formation. For mineral base oils: Base oils in this product are severely solvent refined and/or severely hydrotreated. Chronic mouse skin painting studies of severely treated oils showed no evidence of carcinogenic effects. These results are confirmed on a continuing basis using various screening methods such as Modified Ames Test, IP-346, and/or other analytical methods. For synthetic base oils: The base oils in this product have been tested in the Ames assay and other tests of mutagenicity with negative results. These base oils are not expected to be carcinogenic with chronic dermal exposures.
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Sensitization (summary)
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Not expected to cause sensitization, based on tests of this product, components or similar products.
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Other toxicological data
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Used petrol engine oil have shown evidence of skin carcinogenic activity in laboratory tests when no effort was made to wash the oil off between applications. Used oil from diesel engines did not produce this effect.
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